The new developments and tendency in study on oral insulin were reviewed, and a number of the oral dosage forms of insulin were introduced. 综述口服胰岛素的研究开发动态及发展方向,介绍若干口服给药剂型。
"Review of clinical trials: update on oral insulin spray formulation" was authored by Paolo Pozzilli, MD, Director of Endocrinology and Diabetes, University Campus Bio-Medico, Rome; “临床试验的修改:在口服胰岛素喷雾制剂更新”,由保罗波齐利,医学博士,内分泌和糖尿病,大学校园生物主任,医学生,罗马;
Daniel approaches the strength of the invention is formed from the cellulose plant cell walls may prevent the initial stage after oral administration of insulin was degraded. 丹尼尔发明的方法的优越之处在于,由纤维素组成的植物细胞壁可以在口服后的初始阶段防止胰岛素被降解。
Stability and sustained release of biomaterials as oral insulin vector 生物材料作为口服胰岛素载体的稳定性及缓释作用
Studies on Oral Insulin-Loaded Nanoparticles 口服胰岛素纳米粒的研究
AIM: To study the effect of liposomal formulation factors on its efficiency as a carrier for oral administration of insulin. 目的:研究制剂因素对N三甲基壳聚糖盐酸盐包覆胰岛素脂质体降血糖作用的影响。
Effects of oral administration of insulin and glutamic acid decarboxylase on the incidence of diabetes mellitus in non-obese diabetic mice 口服胰岛素、谷氨酸脱羧酶对NOD小鼠糖尿病发生率的影响
The Mechanism of Oral Immune Prevention of Diabetes by Oral Administration of Insulin in KunMing Mice 口服胰岛素免疫预防昆明株小鼠糖尿病机理的研究
Objective To manufacture a high bioavailability oral insulin that fit the blood glucose change after meals. 目的研制一种生物利用度高适合餐后血糖变化模式的胰岛素口服制剂。
Effect of long-term oral benazepril on insulin resistance in hypertensive premenopausal women 长期口服苯那普利对绝经前高血压妇女胰岛素抵抗的影响
This study examined the effects of oral insulin on the changes of concentrations of insulin in plasma and the functional development of glycometabolism in new born normal piglets and IUGR piglets. 分别给新生正常和子宫内发育迟缓(IUGR)仔猪口饲胰岛素,研究仔猪血浆中胰岛素水平的变化,以及外源性胰岛素对新生仔猪体内糖代谢的影响。
CONCLUSION: The insulin-liposomes double-coated with chitosan and CEC were in favor of improving oral bioavailability of Insulin. 结论:壳聚糖-CEC双层包覆胰岛素脂质体有利于改善胰岛素口服生物利用度。
The application of nano in oral insulin delivery 纳米在胰岛素口服给药中的应用
An Experimental Study on the Oral Administration of Insulin and the Mechanisms of Its Absorption by the Gastrointestinal Tract 胰岛素口服给药的实验研究及其口服吸收机理的探讨
Effects of oral insulin and trypsinized formula milk on small intestinal growth and development in newborn pigs 胰岛素和酶解配方奶粉对初生仔猪小肠生长发育的影响
Enhancing effect of Ulex europaeus agglutinin I modified liposomes on oral insulin absorption in mice 荆豆凝集素修饰脂质体对小鼠口服吸收胰岛素的促进作用
Comparison Studies on Hypoglycemic Effect of Oral with Enema Insulin Microspheres in Diabetic Rats 胰岛素毫微球口服与灌肠对糖尿病大鼠的降糖作用的对比研究
CONCLUSION Various proteolytic enzymes in the GI tract is the predominant barrier which the oral insulin delivery system need to overcome. 结论胃肠道存在的不同种类的蛋白酶对胰岛素的降解是胰岛素口服研究需解决的主要问题。
Study on Oral Administration of Insulin in Enteric Coated Microsphere 胰岛素肠溶微球口服的实验研究
The experimental results provide scientific data for the development of nanoparticle oral insulin agent with high bioavailability factor and for the selection of packing materials with suitable acid base endurance and reductive property. 实验结果为研制具有高生物利用度的胰岛素纳米粒口服制剂及选择具有适当耐酸碱及还原特性的包装材料提供了科学依据。
The results indicate that oral administration of insulin stimulates a increase in mucosal weight and protein content in the small intestine, specifically in the distal ileum, and total activities of lactase, maltase and alkaline phosphatase in the small intestinal contents. 结果表明,口饲胰岛素刺激小肠粘膜尤其是回肠后段粘膜重量和蛋白质含量的增加及小肠内容物中乳糖酶、麦芽糖酶和碱性磷酸酶总活性的升高;
The results show that oral insulin can stimulate the growth and development of small intestine mucosa in IUGR piglets. 结果表明,口饲胰岛素能刺激新生IUGR仔猪小肠粘膜的生长发育及功能的成熟。
Methods: Recent nano progress in the oral insulin delivery has been reviewed in this paper. 方法叙述近年来纳米胰岛素口服给药系统方面取得的一些进展。
The effect and morphology observation of oral administration insulin to NOD mice inducing immune tolerance NOD鼠口服胰岛素诱导免疫耐受的疗效及形态学观察
Objective To Compare hypoglycemic effect of oral with enema insulin microspheres in diabetic rats, so as to manufacture a high bioavailability non-injection insulin preparation. 目的比较自制的胰岛素毫微球给糖尿病大鼠口服、灌肠后的血糖变化,以研制一种生物利用度高的胰岛素非注射制剂。
Advanced research in oral insulin delivery 口服型胰岛素的研究进展
Objective The insulin inclusion complex with@-cyclodextrin was investigated, for developing the oral formulations of insulin. 目的研究胰岛素和β-环糊精的包合作用,为研制口服制剂提供依据。
Oral insulin with easy application and good patient compliance conforms with endogenous insulin secretion pattern. 而胰岛素口服给药是一种患者顺应性好、服用方便的给药方式,符合内源胰岛素的分泌模式。
There are several strategies for the treatment of diabetes mellitus, including oral medicine, insulin injection, pancreas transplantation and islets transplantation. But the benefit from these strategies is limited by many disadvantages. 目前对于糖尿病的治疗,主要有口服药物、注射胰岛素、胰腺移植以及胰岛移植等,然而这些治疗方法都有其缺点。